Adding a certain compound to certain chemical reactions, such as: 92992-85-3, 2-Bromo-3,5-dimethylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 2-Bromo-3,5-dimethylpyridine, blongs to pyridine-derivatives compound. name: 2-Bromo-3,5-dimethylpyridine
To a solution of 2-bromo-3,5-dimethylpyridine (2.0 g)in tetrahydrofuran (30 mL) was added under cooling at-78c 1.59 M n-butyllithium/hexane solution (7.04 mL) and the mixture was stirred for 1 hr. A solution of 1-(tert-butoxycarbonyl)-4-piperidone (2.23 g)in tetrahydrofuran (40 mL) was added, and the mixture was stirred at-78c for 30 min. The reaction mixture was heated to room temperature,saturated aqueous sodium carbonate solution was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine,dried over anhydrous sodium sulfate and concentrated under reduced pressure. The obtained residue was purified by column chromatography (hexane:ethyl acetate) and NH column chromatography (hexane:ethyl acetate)to give 4′-hydroxy-3,5-dimethyl-3′,4′,5′,6′-tetrahydro-2’H-[2,4′]bipyridinyl-1′-carboxylic acid tert-butyl ester (1.69 g).
The synthetic route of 92992-85-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Mitsubishi Tanabe Pharma Corporation; ISHIBUCHI, Seigo; SARUTA, Kunio; HAMADA, Maiko; MATOBA, Nobuatsu; MATSUDAIRA, Tetsuji; SEKI, Maki; TARAO, Akiko; HONJO, Takashi; OGATA, Shingo; KAWATA, Atsushi; MOROKUMA, Kenji; FUJIE, Naoto; AOYAMA, Yukio; (251 pag.)EP3321256; (2018); A1;,
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