Synthetic Route of 849068-61-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 849068-61-7, name is 5-Bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid, molecular formula is C8H5BrN2O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.
Example 108 5-BROMO-LH-PYRROLO [2, 3-B] PYRIDINE-3-CARBOXYLIC acid (2,3-difluoro-phenyl)-amide [0329] To a suspension of 5-BROMO-LH-PYRROLO [2, 3-B] PYRIDINE-3-CARBOXYLIC acid (950 mg, 3.94 mmol) in DCM (20 mL) and DMF (0.1 mL) was added oxalyl chloride (600 mg, 4.72 mmol) slowly. The mixture was stirred at RT for 1 h. To this suspension was then added a solution of 2,3-difluorophenyl amine (610 mg, 4.72 mmol) and triethylamine (800 mg, 7.91 mmol) in DCM (5 mL). The reaction was kept at RT for another 2 h. The solvent was then evaporated, the residue was washed water, and dried for direct use. MS (ES+): m/e= 352 (M+H); LC : 3.5 min.
According to the analysis of related databases, 849068-61-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2005/28475; (2005); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem