Related Products of 14121-36-9, Adding some certain compound to certain chemical reactions, such as: 14121-36-9, name is 2,3,4,6-Tetrachloropyridine,molecular formula is C5HCl4N, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 14121-36-9.
A mixture of 6-amino-1-methyl-4-((2-(pyrimidin-2-yl)propan-2-yl)amino)quinolin- 2(1H)-one (Intermediate A3a, 100 mg, 0.32 mmol), 2,3,4,6-tetrachloropyridine (84 mg, 0.39 mmol), NMP (3.2 mL) and triethylamine (90 uL, 0.65 mmol) was sealed in a vial and purged with argon for 5 mins. The vial was then heated in the microwave for 6h at i40C. Once cooled, DMSO (0.4 mL) was added to the sample which was purified directly using reverse-phase Ci8 column eluting from 30-iOO% methanol in water (each containing 0.i% formic acid) to give the title compound (52 mg) as a pale brown solid. 1H NMR (600 MHz, DMSO-d6) O 9.08 (5, iH), 8.82 (d, J = 4.9 Hz, 2H), 8.25 (d, J = 2.3 Hz, 1H), 7.53 (dd, J = 8.9, 2.3 Hz, 1H), 7.47 (d, J =8.9 Hz, 1H), 7.39 (t, J= 4.9 Hz, 1H), 6.87 (5, 1H), 6.43 (5, 1H), 4.69 (5,1H), 3.42 (5, 3H), i.76 (5, 6H). LCMS (Method T4) Rt = 2.95 mins, m/z 489.0749 [M+H] expected 489.0759 for C22H20Cl3N6O.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 14121-36-9, 2,3,4,6-Tetrachloropyridine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; BELLENIE, Benjamin Richard; CHEUNG, Kwai Ming Jack; DAVIS, Owen Alexander; HOELDER, Swen; HUCKVALE, Rosemary; LLOYD, Matthew Garth; (360 pag.)WO2018/215798; (2018); A1;,
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