Adding a certain compound to certain chemical reactions, such as: 123853-39-4, 4-(2,3-Dichlorophenyl)-5-(methoxycarbonyl)-2,6-dimethyl-1,4-dihydropyridine-3-carboxylic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 123853-39-4, blongs to pyridine-derivatives compound. Product Details of 123853-39-4
The 75mg about 0.21mmol prepared above S14,80mg, about 0.21mmol compound S12,55mg about 0.4mmol K2CO3 in single-neck flask, 5mL DMF, in a nitrogen atmosphere Heated to 50 C, the reaction 2h, cooled to 30 C overnight reaction, until the reaction is complete, add 20mL Water was added and extracted with chloroform, the organic phases were pooled washed with water and saturated brine, dried over anhydrous sodium sulfate Dry, filtered, and solvent was removed by rotary evaporation, the residue was purified by column chromatography to give the present invention provides Compound 9,46mg, a yield of 35%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,123853-39-4, its application will become more common.
Reference:
Patent; JiangsuSimcere Pharmaceutical Company, Ltd; JiangsuSimcere Pharmaceutical Research Co. Ltd.; Chen, Rong; Liu, Fei; Cong, Xin; Feng, Lin; Li, Haidao; Dong, Qingli; (62 pag.)CN102464608; (2016); B;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem