Adding a certain compound to certain chemical reactions, such as: 54232-43-8, 6-Bromo-5-methoxypicolinic acid, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 54232-43-8, blongs to pyridine-derivatives compound. Computed Properties of C7H6BrNO3
4,87g (21 mmol) 6-Bromo-5-methoxy-pyridine-2-carboxylic acid and 4, 17g (25,2 mmol, 1 ,2eq) CDI are suspended in 54ml Me-THF and heated to 50C. After stirring for 3,5h at this temperature the mixture is cooled to 0C in an ice bath and 3,39ml (24,2, 1 , 15eq) triethyl-amine is added. After that 6, 1 g (23, 1 mmol, 1 , 1 eq)of (S)-3- Amino-3-(2-chloro-phenyl)-propionic acid ethyl ester are added within 20 minutes and the resulting mixture is allowed to reach RT and stirred overnight.50 ml water is added, the phases are separated and the organic phase is washed several times with 50ml of saturated NaHC03 solution followed by 50ml of 1 N HCI solution. The organic phase is evaporated in vacuo and 8,43g of product are obtained. Yield: 89%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,54232-43-8, its application will become more common.
Reference:
Patent; SANOFI; RUF, Sven; SADOWSKI, Thorsten; WIRTH, Klaus; SCHREUDER, Herman; BUNING, Christian; WO2012/101197; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem