Electric Literature of 628-13-7, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 628-13-7 as follows.
EXAMPLE 4 Preparation of 4-cyano-4′-hydroxybiphenyl 1 g of p-(4-methoxyphenyl)benzonitrile and 3 g of pyridium chloride are introduced under nitrogen into a 50 ml two-necked flask. The mixture is heated at 200 C. for 6 hours then it is left to cool down. 5 ml of pyridine and 5 ml of 1 N hydrochloric acid are poured in at 110 C. The reaction mixture is extracted with chloroform at ambient temperature. The organic phases are collected and washed with water, (2*30 ml), dried over anhydrous magnesium sulphate and concentrated under vacuum. After recrystallization from an ethyl acetate/heptane mixture, the sought product is obtained (yield: 50%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,628-13-7, its application will become more common.
Reference:
Patent; Societe d’Expansion Scientifique Expansia; US6046352; (2000); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem