Application of 867279-13-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 867279-13-8, name is 4-Bromo-2-chloro-5-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
4-(4,4,5,5-Tetramethyl- [1,3,2]dioxaborolan-2-yl)-1-(2,4,6-trimethylbenzensulfonyl)-1H pyrrole-2- carboxylic acid methyl ester (125 mg, 0.29 mmol, 0.6 equiv. ) and 4-bromo-2- chloro-5-methylpyridine (96 mg, 0.47 mmol, 1.0 equiv. ) were dissolved in benzene (4 mL). After adding methanol (0.94 mL) and aqueous Na2C03, Pd (PPh3)4 (108 mg, 0.094 mol, 0.2 equiv. ) was then added and the resulting mixture was heated at reflux for 16 hours. The reaction mixture was dissolved in ethyl acetate and washed with water. After drying the organic layer over Na2S04, the solvent was removed under reduced pressure. The crude material was purified by reversed phase HPLC (acetonitrile/ water/TFA), yielding the title compound as a colorless solid (54 mg, 0.125 mmol, HPLC Rt 9.087 min, ES+ 433.0, ES- 431.0).
According to the analysis of related databases, 867279-13-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; VERTEX PHARMACEUTICALS, INCORPORATED; WO2005/100342; (2005); A1;,
Pyridine – Wikipedia,
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