As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 185017-72-5, name is 3-Bromo-2-chloro-6-picoline, molecular formula is C6H5BrClN, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 185017-72-5
Example 12Preparation of lambda/-[2-amino-1-(phenylmethyl)ethyl1-6-chloro-5-(1-methyl-1 H-pyrazol- 5-yl)-2-pyridinecarboxamidea) S-bromo^-chloro-beta-methylpyridine N-oxideTo a solution of S-bromo^-chloro-beta-methylpyridine (1 g, 4.84 mmol) and urea hydrogen peroxide (91 1 mg, 9.69 mmol) in DCM (24 ml.) at 0 0C was added trifluoroacetic anhydride (1.4 ml_, 9.69 mmol). After warming to 25 0C over 12h, the solution was partitioned between H2O-DCM. The aqueous phase was washed several times with DCM and the combined organic fractions were dried over Na2SO4, concentrated and purified via column chromatography (silica, 1% MeOH in DCM) yielding the title compound (1.1 g, quant.) as a white solid: LCMS (ES) m/z = 223 (M+H)+.b) N-[2-amino
With the rapid development of chemical substances, we look forward to future research findings about 185017-72-5.
Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2008/121786; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem