In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 13362-30-6, name is Ethyl 2-aminoisonicotinate, the common compound, a new synthetic route is introduced below. Product Details of 13362-30-6
Example 97 Preparation of ethyl 2-valeramidoisonicotinate ([9]-(94)-467) The compound ([9]-(93)-467′) (2.0691 g) prepared in Example 96 was dissolved in anhydrous pyridine (25 ml), and valeryl chloride (1.5 ml) was added dropwise to the solution with stirring and cooling on ice. After stirring and cooling on ice for 1 hour, the reaction solution was poured into ice water. The solution was extracted with ethyl acetate, washed with water and saturated brine, dried over anhydrous sodium sulfate, and concentrated. The resulting light yellow oil (3.2548 g) was purified by silica gel column chromatography (Kieselgel 60=160 g, hexane/ethyl acetate=5/1) to obtain the above-captioned compound ([9]-(94)-467) (3.0820 g) as white crystals. Melting point: 46.0-47.0 C. 1 H-NMR (500MHz, CDCl3) delta: 0.96 (t, 3H), 1.41 (t, 3H), 1.43 (sext, 2H), 1.74 (quint, 2H), 2.42 (t, 2H), 4.41 (q, 2H), 7.60 (dd, 1H), 8.04 (bs, 1H), 8.38 (dd, 1H), 8.74 (s, 1H)
The synthetic route of 13362-30-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Kureha Chemical Industry Co., Ltd.; US5696118; (1997); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem