In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 161117-83-5, name is tert-Butyl (2-methoxypyridin-3-yl)carbamate, the common compound, a new synthetic route is introduced below. SDS of cas: 161117-83-5
Under a nitrogen atmosphere, the entire batch of compound II in tetrahydrofuran solution, 70.2 tetramethylethylenediamine (0.6 mol, 1.5 eq) was added to the reaction flask.The temperature was lowered to -30 C, and 263.4 g of n-butyl lithium n-hexane solution (0.96 mol, 2.4 eq) was added dropwise. After the dropwise addition, the reaction was incubated for 2 hours.After the heat preservation was completed, 92.7 g of N-formylmorpholine (0.8 mol, 2.0 eq) was added and stirred for 30 min.After the reaction is completed, the temperature is controlled at 0-20 C, the pH value is adjusted to 5-7 with 3N hydrochloric acid, the layers are separated, 200g of methylene chloride is added to the aqueous phase, and extraction is performed once.Combine the organic phases, concentrate under reduced pressure until a large amount of solid precipitates, add 300g of n-heptane,After steaming to a certain volume, beating and filtering, 81.3 g of yellow solid (80% yield in two steps) is obtained as compound III.
The synthetic route of 161117-83-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Cheng Da Pharmaceutical Co., Ltd.; Shi Yuhua; Qian Wei; Feng Yu; Huang Xing; Dang Junkui; Wang Zhipeng; Dong Changming; Xu Hong; Huang Zongxi; Chen Ye; Shen Huafei; Zhang Jun; (12 pag.)CN110964011; (2020); A;,
Pyridine – Wikipedia,
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