Application of 52378-63-9 , The common heterocyclic compound, 52378-63-9, name is (3-Aminopyridin-2-yl)methanol, molecular formula is C6H8N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
0.5 mmol of 3-amino-2-hydroxymethylpyridine was added to the schlenk tube,0.5 millimoles of phenethyl alcohol, 0.5 millimoles of potassium t-butoxide,0.005 mmol dodecacarbonyltrisodium,0.015 mmol of 4,5-bisdiphenylphosphine-9,9-dimethylxanthene and 1.2 ml of t-amyl alcohol were charged, protected with N2, and the mixture was stirred at 130 C for 10 hours.Stop heating and stirring, cooled to room temperature, diluted reaction solution, filtered,The solvent was distilled off under reduced pressure and the residue was purified by column chromatography to obtain the target product. The column eluant was a petroleum ether: ethyl acetate mixed solvent with a volume ratio of 12: 1, and the yield was 46%.
The synthetic route of 52378-63-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; South China University of Technology; Zhang Min; Xiong Biao; (19 pag.)CN104876929; (2016); B;,
Pyridine – Wikipedia,
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