Electric Literature of 100202-78-6, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 100202-78-6 as follows.
EXAMPLE 14 SYNTHESIS OF (2-DIMETHYLAMINO-3,5,6-TRIFLUOROPYRIDIN-4-YL)METHYL CIS-3-(2-CHLORO-3,3,3-TRIFLUOROPROPENYL)-2,2-DIMETHYLCYCLOPROPANECARBOXYLATE By the method of Example 2, 0.5 g (0.002 mole) of 2-dimethylamino-4-hydroxymethyl-3,5,6-trifluoropyridine (from Example 13) was reacted with 0.6 g (0.002 mole) of cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarbonyl chloride to produce, after purification through a short silica gel column and the Chromatotron, 0.45 g of (2-methoxy-3,5,6-trifluoropyridin-4-yl)methyl cis-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethylcyclopropanecarboxylate as an oil, Compound No. 20 of the tables below. Analysis calc’d for C17 H17 ClF6 N2 O2: C 47.38; H 3.95; N 6.50; Found: C 47.69; H 4.09; N. 6.55.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,100202-78-6, its application will become more common.
Reference:
Patent; FMC Corporation; US4701464; (1987); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem