Adding a certain compound to certain chemical reactions, such as: 1256811-02-5, 1-(5-Bromo-2-methoxypyridin-3-yl)ethanone, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, HPLC of Formula: C8H8BrNO2, blongs to pyridine-derivatives compound. HPLC of Formula: C8H8BrNO2
[0118] 1-(5-Bromo-2-methoxy-pyridin-3-yl)ethanone (XXXVI) (200 mg, 1.404mmol) was dissolved in N,N-dimethylformamidedimethyl acetal (DMFDMA) (1.7 ml, 14.03 mmol), and the resulting solution was stirred with reflux for 24 hrs.The solution was cooled and evaporated and concentrated under reduced pressure to give a yellow solid. The solid wasdissolved in methanol (MeOH) (1 mL) and 25 % sodium methoxide (NaOMe) (186 mL, 6.212 mmol) and guanidinhydrochloride (498.0 mg, 6.212 mmol) were added dropwise to the resulting solution. And then, the solution was stirredwith reflux for 24 hrs and cooled. The solution was diluted with ethylacetate (EA) and washed with water, and the organicsolvent was dried over anhydrous magnesium sulfate (MgSO4), filtered, and evaporated and concentrated under reducedpressure to give the title compound (20.3 mg, 55 %).1H NMR (400 MHz, CDCl3) delta 8.50 (s, 1H), 8.43 (s, 1H), 7.85 (d, J = 8.0 Hz, 1H), 7.35 (d, J = 7.6 Hz, 1H), 4.07 (s, 3H).
The synthetic route of 1256811-02-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Beyondbio Inc.; MIN, Changhee; OH, Byungkyu; KIM, Yongeun; PARK, Changmin; (98 pag.)EP3255042; (2017); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem