Adding a certain compound to certain chemical reactions, such as: 847729-27-5, Methyl 2-chloro-5-fluoronicotinate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C7H5ClFNO2, blongs to pyridine-derivatives compound. Computed Properties of C7H5ClFNO2
(b) Methyl 5-fluoro-2-(methylamino)nicotinate. A mixture of methyl 2-chloro-5-fluoronicotinate (3.82 g, 20 mmol) and K2CO3 (5.6 g, 40 mmol) in THF (25 mL) was stirred under nitrogen for 15 minutes. To the mixture was added a 2 M solution of methylamine in THF (10 mL, 20 mmol), and stirring was continued for 63 hours. The reaction mixture was filtered over Celite, and the filtrate was evaporated under reduced pressure. The residue was purified by silica gel column chromatography (DCM) to give the title compound as an orange oil. MS (ESI, pos. ion) m/z: 185 (M+l).
The synthetic route of 847729-27-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN INC.; WO2008/76425; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem