Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 2897-43-0, name is 2,6-Dichloro-3-nitropyridin-4-amine. A new synthetic method of this compound is introduced below., Recommanded Product: 2,6-Dichloro-3-nitropyridin-4-amine
(6) 2,4,6-trichloro-3-nitropyridine 2,6-dichloro-3-nitropyridine-4-amine (2.27 g, 10.9 mmol) was added to 48 mL concentrated hydrochloric acid, and cooled to 0-5 C. To the solution was added sodium nitrite (2.26 g, 32.7 mmol) in batches. After the addition of sodium nitrite, the reaction solution was stirred for 1 h at 0-5 C , and then stirred for 2 h at 25 C, adjusted to pH = 7 with 40 % sodium hydroxide solution, and extracted with ethyl ether. After the organic phase was dried (Na2SO4) and concentrated, it was subjected to column chromatography eluted with petroleum ether to afford 2 g white solid with a yield of 80.7%.
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Reference:
Patent; Xuanzhu Pharmaco., Ltd.; EP2524917; (2012); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem