Related Products of 33252-28-7, Adding some certain compound to certain chemical reactions, such as: 33252-28-7, name is 6-Chloronicotinonitrile,molecular formula is C6H3ClN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 33252-28-7.
To a suspended mixture of 6-chloronicotinonitrile (7g, 50.8 mmol) in EtOH(50 rnL), was added NH2NH2 (1Og, 310.2mmol). The mixture was stirred at room temperature for 10 min, and then 60 0C for 5h. The mixture was cooled to room temperature. The solids were filtered out, washed with water and dried under high vacuum to give 6- hydrazinylnicotinonitrile (3.5g). Compound 6 was prepared from 6-hydrazinylnicotinonitrile following the procedure of the synthesis of compound 4. 1H NMR (400 MHz, CDC13- CD3OD 10:1) delta ppm 11.37 (s, IH), 8.70 (t, J= 1.2 Hz, 1 H), 8.14 (s, IH), 8.1 l(dd, J= 1.04 and 9.52 Hz, 1 H), 7.96 (dd, J= 1.12 and 9.52 Hz, 1 H), 7.61 ( dd, J= 1.52 and 9.48 Hz, 1 H), 7.38 (d, J=9.0 Hz, 1 H), 1.77 (m, 1 H), 1.06 (m, 2 H), 0.90 (m, 2H) ESI-MS:m/z 377.2 (M+H)+.
According to the analysis of related databases, 33252-28-7, the application of this compound in the production field has become more and more popular.
Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; BRESSI, Jerome, C.; CHU, Shaosong; ERICKSON, Philip; KOMANDLA, Mallareddy; KWOK, Lily; LAWSON, John, D.; STAFFORD, Jeffrey, A.; WALLACE, Michael, B.; ZHANG, Zhiyuan; DAS, Sanjib; WO2010/19899; (2010); A1;,
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