Application of 3430-21-5 ,Some common heterocyclic compound, 3430-21-5, molecular formula is C6H7BrN2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
6-Amino-5-methylnicotinonitrile. A mixture of 2-Amino-5-bromo-3-methylpyridine (15.49 g, 82.8 mmol) and Cu(I)CN (9.27 g, 103.5 mmol) in DMF (160 mL) was heated at 150 C. for 24 h. The reaction mixture was poured onto water and the solid which formed was extracted by using ethylacetate (600 mL, 3 times) from aq. NH4OH. The solvent was evaporated and the precipitate purified by chromatography (SiO2, hexanes/EtOAc 4:6). Yield 70%, mp 198-200 C., (Lit. mp 203-205 C.; see Dunn A. D. and Norrie R. J. Prakt. Chem./Chem.-Ztg, 338 (7), 663-666 (1996). Lit. melting point not reported via palladium-catalyzed cyanation; see Maligres, P. et al., Tetrahedron Lett., 40, 8193-8195 (1999).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3430-21-5, 5-Bromo-3-methylpyridin-2-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Boykin, David W.; Tidwell, Richard R.; Wilson, W. David; Ismail, Mohamed A.; US2005/282853; (2005); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem