Electric Literature of 1211517-76-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1211517-76-8, name is 3-Bromo-5-fluoro-4-methylpyridine. This compound has unique chemical properties. The synthetic route is as follows.
Step 2: A mixture of the intermediate of step 1 (150 mg, 475 pmol), 3-bromo-5-fluoro-4-methylpyridine(108 mg, 570 pL), Cu(l)l (6 mg, 24 pmol), K2C03 (132 mg, 964 pmol) and N,N?-dimethyl ethylendiamine(30 mg, 81 pmol) in toluene (0.5 mL) was heated in a sealed tube to 120 C under N2 atmosphereovernight. The volatiles were removed under reduced pressure and the residue was purified bychromatography (Interchim cartridge 5OSiHP /12 g, EtOAc/Cy) to yield the title compound of example17(111 mg,55%).LC-MS (Method 2): m/z [M-?-H] = 425.1(MW calc. = 424.76); R = 0.79 mm. Step 2: A mixture of the intermediate of step 1 (150 mg, 475 pmol), 3-bromo-5-fluoro-4-methylpyridine(108 mg, 570 pL), Cu(l)l (6 mg, 24 pmol), K2C03 (132 mg, 964 pmol) and N,N?-dimethyl ethylendiamine(30 mg, 81 pmol) in toluene (0.5 mL) was heated in a sealed tube to 120 C under N2 atmosphereovernight. The volatiles were removed under reduced pressure and the residue was purified bychromatography (Interchim cartridge 5OSiHP /12 g, EtOAc/Cy) to yield the title compound of example17(111 mg,55%).LC-MS (Method 2): m/z [M-?-H] = 425.1(MW calc. = 424.76); R = 0.79 mm.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 1211517-76-8, 3-Bromo-5-fluoro-4-methylpyridine.
Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; VOSS, Felix; WACHTEN, Sebastian; KLESS, Achim; RITTER, Stefanie; WO2015/90580; (2015); A1;,
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