Related Products of 628691-93-0, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 628691-93-0, name is 2-Chloro-3-fluoroisonicotinic acid. This compound has unique chemical properties. The synthetic route is as follows.
Diphenylphosphoryl azide (DPPA) (129 mmol) wasadded to a mixture of 2-chloro-3-fluoro-pyridine-4-carbox- ylic acid (85.7 mmol), Et3N (257 mmol) in 1:1 tert-l3uOH/ toluene (200 mE). The mixture was heated at 110 C. for 4 h. Mixture was diluted with H20 and extracted with DCM. The organic layer was dried (Na2504) and concentrated. The residue was purified by flash column chromatography (5i02, 100:0 to 80:20 DCM/EtOAc) to yield the desired product tert-butyl N-(2-chloro-3-fluoro-4-pyridyl)carbamate.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 628691-93-0, 2-Chloro-3-fluoroisonicotinic acid.
Reference:
Patent; GALAPAGOS NV; Menet, Christel Jeanne Marie; Mammoliti, Oscar; Blanc, Javier; Orsulic, Mislav; Roscic, Maja; (81 pag.)US9440929; (2016); B2;,
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