Introduction of a new synthetic route about 185017-72-5

At the same time, in my other blogs, there are other synthetic methods of this type of compound,185017-72-5, 3-Bromo-2-chloro-6-picoline, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 185017-72-5, 3-Bromo-2-chloro-6-picoline, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Computed Properties of C6H5BrClN, blongs to pyridine-derivatives compound. Computed Properties of C6H5BrClN

Example 3: Lambda/-{[1 -(4-Chlorophenyl)cyclopropyl]methyl}-6-methoxy-5-(4-methyl-1 H- imidazol-1 -yl)pyridine-2-carboxamide (3)Step 1 . Synthesis of 3-bromo-2-methoxy-6-methylpyridine (C14). A mixture of 3-bromo-2-chloro-6-methylpyridine (75.4 g, 0.365 mol) and sodium methoxide (59.1 g, 1 .1 mol) in absolute methanol (700 mL) was heated at reflux for 5 days. Additional sodium methoxide (1 equivalent) was added, and the mixture was heated at reflux for 2 days. The solvent was removed under reduced pressure, and the residue was partitioned between water and dichloromethane. The organic layer was washed with water, dried over sodium sulfate, filtered and concentrated to provide the title product. Yield: 70.3 g, 0.348 mol, 95%.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,185017-72-5, 3-Bromo-2-chloro-6-picoline, and friends who are interested can also refer to it.

Reference:
Patent; PFIZER INC.; AM ENDE, Christopher William; JOHNSON, Douglas Scott; O’DONNELL, Christopher John; PETTERSSON, Martin Youngjin; SUBRAMANYAM, Chakrapani; WO2011/48525; (2011); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem