Adding a certain compound to certain chemical reactions, such as: 867279-13-8, 4-Bromo-2-chloro-5-methylpyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 867279-13-8, blongs to pyridine-derivatives compound. Recommanded Product: 867279-13-8
Intermediate 8 (0496) 1-terf-But l 2-methyl 4-(2-chloro-5-methylpyridin-4-yl)- IH-pyrrole- 1 ,2-dicarboxylate (0497) (0498) Pd(Ph3P)4 (2.80 g, 2.42 mmol) was added to 1-tert-butyl 2-methyl 4-(4,4,5,5-tetramethyl- l,3,2-dioxaborolan-2-yl)-lH-pyrrole-l,2-dicarboxylate (17.01 g, 48.43 mmol), 4-bromo-2- chloro-5-methylpyridine (10 g, 48.43 mmol) and Na2C03 (10.27 g, 96.87 mmol) in 1,4- dioxane (150 mL),water (30 mL) at 20 C under nitrogen. The resulting solution was stirred at 80 C for 4 hours. The reaction mixture was poured into water (200 mL), extracted with EtOAc (3 x 200 mL), the organic layer was dried over Na2S04, filtered and evaporated to afford yellow oil. The crude product was purified by flash silica (0499) chromatography (elution gradient 9 to 10% EtOAc in petroleum ether). Pure fractions were evaporated to dryness to afford l-tert-butyl 2-methyl 4-(2-chloro-5-methylpyridin-4-yl)- lH-pyrrole-l,2-dicarboxylate (Intermediate 8; 7.80 g, 45.9%) as a colourless oil. FontWeight=”Bold” FontSize=”10″ Eta NMR (300 MHz, CDC1 ) delta 1.64 (9H, s), 2.41 (3H, s), 3.91 (3H, s), 7.05 (1H, s), 7.32 (1H, s), 7.55 (1H, s), 8.25 (1H, s). m/z (ES+), [M+H]+ = 351.
The synthetic route of 867279-13-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; WARD, Richard, Andrew; JONES, Clifford, David; FERON, James, Lyman; (80 pag.)WO2017/80980; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem