Related Products of 123853-39-4 ,Some common heterocyclic compound, 123853-39-4, molecular formula is C16H15Cl2NO4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step 1 preparation of intermediate 2.0 kg (5.61mol) inputs 10L in acetonitrile, inputs under stirring chloro-butyrate 850g (6.22mol) and potassium carbonate 860g (6.22mol), heating to reflux reaction 4-6h, cooling to room temperature, filter, filtrates in 40-50 C concentrated under reduced pressure to dry, subsequently joined 4L ethyl acetate, reflux is dissolved, and 45g activated carbon decolourizations 5-15min, hot filtering, filtrates in 30-40 C dropwise 7L-hexane crystallization, filtration, 40-50 C decompression drying to obtain the butyric acid clevidipine 2.38 kg, yield 92.89%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,123853-39-4, its application will become more common.
Reference:
Patent; Hefei long promise Pharmaceutical Technology Co; Wu, biao; Ling, lin; Wang, zhouhong; Dai, yij; (10 pag.)CN105461619; (2016); A;,
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