Application of 1137-67-3 ,Some common heterocyclic compound, 1137-67-3, molecular formula is C12H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
General procedure: 2-Substituted benzimidazole (0.01 M) was added to the ethanolic solution of benzamide (0.01M). Formaldehyde (37-41% w/v) (0.01 M) was added and the reaction mixture was then adjusted to the pH of 3.5 with concentrated HCl. The mixture was kept at efficient ice cooling for half an hour. Then, it was refluxed with stirring at 80 C for 10-12h. Formaldehyde (37-41% w/v) was added to the reaction mixture in portions for completion of the reaction. End of reaction was monitored by TLC. Reaction mixture was kept in refrigerator overnight. Solvent was evaporated under reduced pressure and product was collected, washed with water and recrystallized from ethanol.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1137-67-3, its application will become more common.
Reference:
Article; Sethi, Ritchu; Arora, Sandeep; Saini, Deepika; Singh, Thakur Gurjeet; Jain, Sandeep; Acta poloniae pharmaceutica; vol. 74; 5; (2017); p. 1413 – 1425;,
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