As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 59020-10-9, name is 3-(Tributylstannyl)pyridine, molecular formula is C17H31NSn, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. COA of Formula: C17H31NSn
General procedure: Aryl halide (0.5 mmol), base (1 mmol), CuI (20 mol %), alkylstannylpyridine(0.75 mmol), and catalyst (1 mol %) were dissolvedin DMF (2 mL) in a 10 mL vial and heated at a specific temperatureunder N2 for 12 h. After the reaction was complete, and thenquenched with water. The mixture was diluted with ethyl acetate(10 mL), filtered through a pad of Celite, and followed by extractionwith ethyl acetate for three times. The combined organic layer wasdried over anhydrous Na2SO4, filtered, and evaporated under reducedpressure. The residual was purified by flash chromatographyon silica gel (ethyl acetate/hexane) to give the desired product.4.3.5 3-(4-Methoxyphenyl)pyridine (3ea) 14 Yellow solid, mp 57-58 C; 1H NMR (400 MHz, CDCl3): delta=8.82 (s, 1H), 8.54 (d, J=4.08 Hz, 1H), 7.83 (dt, J=7.88, 1.88 Hz, 1H), 7.52 (d, J=8.72 Hz, 2H), 7.32-7.35 (m, 1H), 7.01 (d, J=8.72 Hz, 2H), 3.86 (s, 3H); 13C NMR (100 MHz, CDCl3): delta=55.4, 114.5, 123.5, 128.2, 130.2, 133.9, 147.9, 148.0, 159.7; HRMS-ESI (m/z): [M+H]+ calcd for C12H12NO+: 186.0913, found: 186.0915.
With the rapid development of chemical substances, we look forward to future research findings about 59020-10-9.
Reference:
Article; Ma, Gaizhi; Leng, Yuting; Wu, Yusheng; Wu, Yangjie; Tetrahedron; vol. 69; 2; (2013); p. 902 – 909;,
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