With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.603311-76-8, name is Ethyl 2-(6-bromoimidazo[1,2-a]pyridin-3-yl)acetate, molecular formula is C11H11BrN2O2, molecular weight is 283.12, as common compound, the synthetic route is as follows.Recommanded Product: Ethyl 2-(6-bromoimidazo[1,2-a]pyridin-3-yl)acetate
General procedure: To a 5 mL Schlenk tube were added aryl / heteroaryl acetates 3 (1.0 mmol, 1.0 equiv.), vinyl diphenylsulfonium triflate (434.4 mg, 1.2 mmol, 1.2 equiv.) and DMSO (5 mL). The mixture was stirred at room temperature for 2 min and to the mixture was added DBU (456 mg, 3 mmol, 3.0 equiv.). The mixture was stirred for 12 hours at room temperature till the reaction was complete. To the resulting mixture was added saturated ammonium chloride solution (25 mL), and the mixture was then extracted with EtOAc (3 x 150 mL). The combined organic layers were washed with H2O (2 x 30 mL), dried with anhydrous sodium sulfate. After concentration, product 4 was purified using column chromatography on silica gel using an appropriate eluent.
At the same time, in my other blogs, there are other synthetic methods of this type of compound,603311-76-8, Ethyl 2-(6-bromoimidazo[1,2-a]pyridin-3-yl)acetate, and friends who are interested can also refer to it.
Reference:
Article; Zhou, Mingwei; Hu, Yimin; En, Ke; Tan, Xuefei; Shen, Hong C.; Qian, Xuhong; Tetrahedron Letters; vol. 59; 14; (2018); p. 1443 – 1445;,
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