Reference of 10177-08-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 10177-08-9, name is 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid. This compound has unique chemical properties. The synthetic route is as follows.
To a solution of 2-Oxo-5-phenyl-l,2-dihydro-pyridine-3-carboxylic acid (44 g, 0.20 mmol) in tetrahydrofuran (5 mL) were successively added aniline (20 muL, 0.23 mmol), hydroxybenzotriazole (30 mg, 0.23 mmol), dimethylaminopyridine (27 mg, 0.23 mmol) and EDC (43 mg, 0.23 mmol). The reaction mixture was stirred at room temperature for 16 hours. The solvent was removed in vacuo and the residue was purified by silica gel chromatography eluting with DCM containing 10percent of MeOH to afford the title compound as a white solid (20 mg, 34percent yield). MS (ES+) 291. deltaH (DMSOd6) 7.2 (3H, m), 7.9 (IH, t), 8.5 (IH, d), 8.6 (2H, m), 9.3 (IH, s).
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 10177-08-9, 2-Oxo-5-phenyl-1,2-dihydropyridine-3-carboxylic acid.
Reference:
Patent; VERTEX PHARMACEUTICALS INCORPORATED; WO2006/65946; (2006); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem