Reference of 1241752-31-7 ,Some common heterocyclic compound, 1241752-31-7, molecular formula is C8H10BrNO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
a. Preparation of Compound To a solution of intermediate 2c (2-ethoxy-3-methoxy-5-bromopyridine) (140 mg, 0.5 mmol) in 4 ml dioxane: water (3:1) was added 4-(fluoromethyl)phenylboronic acid (104 mg, 0.75 mmol) and potassium carbonate (138 mg, 1.0 mmol). The resulting mixture was degassed for 15 minutes after which Pd (PPh3)4 (60 mg, 0.06 mmol) was added and the mixture was further degassed for 15 minutes. The reaction mixture was then heated at 100 C for 12 hours. After cooling to room temperature, the reaction mixture was diluted with ethyl acetate and was washed with saturated sodium bicarbonate, followed by brine. The organic phase was dried with sodium sulfate and concentrated under reduced pressure to afford crude product which was purified by ISCO flash chromatography using 10%- 100% EtOAC in hexane to afford 1 19 mg product pure product (yield: 96%); lU NMR (300 MHz, CDC13) delta: 7.84(s, 1H), 7.44 (m, 2H), 7.14-7.08 (m, 3H), 4.46 (qt, J = 7.2 Hz, 2H), 3.88 (s, 3H), 1.44 (qt, J= 7.2 Hz, 3H).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1241752-31-7, its application will become more common.
Reference:
Patent; RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY; LAVOIE, Edmond J.; BAUMAN, Joseph David; PARHI, Ajit; SAGONG, Hye Yeon; PATEL, Disha; ARNOLD, Eddy; DAS, Kalyan; VIJAYAN, Suyambu Kesava; WO2014/43252; (2014); A2;,
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