Introduction of a new synthetic route about 1357947-08-0

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1357947-08-0, 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, and friends who are interested can also refer to it.

Adding a certain compound to certain chemical reactions, such as: 1357947-08-0, 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Formula: C6H3BrIN3, blongs to pyridine-derivatives compound. Formula: C6H3BrIN3

The product from Step a (1.18 g, 3.65 mmol) was combined with doubly SEM-protected 1 ,3-dihydro-5-(4,4,5,5-tetramethyl- 1 ,3,2-dioxaborolan-2-yl)-2//-bendimidazol-2- one (1.9 g, 3.65 mmol), and Pd(dppf)Ch (267 mg, 0.365 mmol) in dioxane (36.5 ml). A solution of 1 M aqueous Na2C03 (11.0 ml) was added, and the solution was sparged with nitrogen for one minute. The reaction was sealed and heated to 1 10 C for 15 hours, at which point the reaction was concentrated onto Celite and purified by flash chromatography over silica gel (ethyl acetate/hexanes 0% to 40%). Yield: 247 mg, (12%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1357947-08-0, 5-Bromo-3-iodo-1H-pyrazolo[3,4-c]pyridine, and friends who are interested can also refer to it.

Reference:
Patent; ARCUS BIOSCIENCES, INC.; BEATTY, Joel; DEBIEN, Laurent Pierre Paul; DREW, Samuel Lawrie; FOURNIER, Jeremy; GRANGE, Rebecca Louise; JACOB, Steven Donald; JEFFREY, Jenna Leigh; LAWSON, Kenneth V.; LELETI, Manmohan Reddy; LINDSEY, Erick Allen; MANDAL, Debashis; POWERS, Jay Patrick; TRAN, Anh Thu; THOMAS-TRAN, Rhiannon; YAN, Xuelei; (164 pag.)WO2020/46813; (2020); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem