Synthetic Route of 55899-13-3, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 55899-13-3, name is 1-Amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzenesulfonate. A new synthetic method of this compound is introduced below.
Methyl 6-[(6-bromo-2-phenylpyrazolo[1,5-a]pyridin-3-yl)carbonyl]pyridine-2-carboxylate After potassium carbonate (6.25 g) was added to an N,N-dimethylformamide (22.6 mL) solution of methyl 6-(1-oxo-3-phenyl-2-propyn-1-yl)pyridine-2-carboxylate (3.00 g) and 1-amino-3-bromopyridinium 2,4,6-trimethylbenzenesulfonate (7.71 g) at room temperature, the mixture was stirred at room temperature for 2 hours. The reaction solution was diluted with ethyl acetate, washed with water and saturated saline, and then dried over anhydrous sodium sulfate. The solvent was evaporated and then the residue thus obtained was purified by silica gel column chromatography (n-hexane:ethyl acetate = 3:1) to obtain a title compound as a yellow crystal (1.35 g). 1H-NMR (400 MHz, CDCl3) delta 3.85 (3H, s), 7.05 (2H, t, J = 7.9 Hz), 7.13 (1H, t, J = 7.9 Hz), 7.23 (2H, d, J = 7.9 Hz), 7.59 (1H, dd, J = 9.1 and 1.8 Hz), 7.86 (1H, t, J = 7.9 Hz), 7.94 (1H, d, J = 7.9 Hz), 8.00 (1H, dd, J = 7.9 and 1.2 Hz), 8.28 (1H, d, J = 9.1 Hz), 8.73 (1H, d, J =1.8 Hz).
At the same time, in my other blogs, there are other synthetic methods of this type of compound,55899-13-3, 1-Amino-3-bromopyridin-1-ium 2,4,6-trimethylbenzenesulfonate, and friends who are interested can also refer to it.
Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; Kissei Pharmaceutical Co., Ltd.; SETO, Shigeki; UMEI, Kentaro; NISHIGAYA, Yosuke; TANIOKA, Asao; KONDO, Tatsuhiro; KONDO, Atsushi; TATANI, Kazuya; KAWAMURA, Naohiro; EP2669285; (2013); A1;,
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