Application of 183428-91-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.183428-91-3, name is 2-Amino-3-methyl-5-cyanopyridine, molecular formula is C7H7N3, molecular weight is 133.15, as common compound, the synthetic route is as follows.
Step II: 6-Amino-5-methyl-pyridine-3-carboxylic acid To a stirred suspension of 6-amino-5-methyl-pyridine-3-carbonitrile (6.0 g, 45.0 mmol) in water (40 mL) was added sodium hydroxide (5.4 g, 135.2 mmol) and refluxed for 4 h. Reaction mixture was cooled to room temperature and filtered through Buchner funnel. Filtrate was neutralized with 4N HCl. Solid formed was filtered through Buchner funnel and dried under high vacuum to furnish 6.0 g (88%) of titled intermediate as a white solid. 1H NMR (400 MHz, CDCl3): delta 2.05 (s, 3H), 6.53 (s, 2H), 7.66 (s, 1H), 8.37 (d, J=2.0 Hz, 1H), 12.29 (brs, 1H). MS (ES) m/z 153.0 (M+1).
Statistics shows that 183428-91-3 is playing an increasingly important role. we look forward to future research findings about 2-Amino-3-methyl-5-cyanopyridine.
Reference:
Patent; Kharul, Rajendra; Bhuniya, Debnath; Mookhtiar, Kasim A.; Singh, Umesh; Hazare, Atul; Patil, Satish; Datrange, Laxmikant; Thakkar, Mahesh; US2015/65464; (2015); A1;,
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