Related Products of 1233205-73-6, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.1233205-73-6, name is 2-Ethynyl-6-fluoropyridine, molecular formula is C7H4FN, molecular weight is 121.11, as common compound, the synthetic route is as follows.
To a solution of the compound obtained in the previous section (1.45 g, 4.54 mmol) and the reference example 2 (0.50 g, 4.13 mmol) in AcN (20 ml_ ) at 0 5C, a DBU (1.24 ml_, 8.26 mmol) solution in AcN (7 ml_) was slowly added. The resulting mixture was heated at 50 0C for 18 h. After that, was cooled and concentrated to dryness. The crude product obtained was chromatographed over silica gel using hexane/EtOAc mixtures of increasing polarity as eluent, to afford 0,48 g of the desired compound (45% yield). LC-MS (Method 2): tR = 3.03 min; m/z = 239 (MH+).
Statistics shows that 1233205-73-6 is playing an increasingly important role. we look forward to future research findings about 2-Ethynyl-6-fluoropyridine.
Reference:
Patent; PALAU PHARMA, S. A.; SALAS SOLANA, Jorge; ALMANSA ROSALES, Carmen; COMELLES ESPUGA, Josep; FONTES USTRELL, Montserrat; SOLIVA SOLIVA, Robert; PASTOR PORRAS, Jose, Javier; WO2010/72823; (2010); A1;,
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