Adding a certain compound to certain chemical reactions, such as: 15862-50-7, 3-Bromo-2-methoxy-5-nitropyridine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: pyridine-derivatives, blongs to pyridine-derivatives compound. category: pyridine-derivatives
A mixture of 3-bromo-2-methoxy-5-nitropyridine (30b; 5.56 g, 23.86 mmol), potassium trifluoro(vinyl)borate (6.39 g, 47.7 mmol), PdCl2Amphos2(0.338 g, 0.477 mmol), and potassium carbonate (35.8 mL, 71.6 mmol) in dioxane (119 mL) was stirred at 80 C for 30 min. The reaction mixture was then diluted with DCM (200 mL) and washed with saturated aqueous ammonium chloride (2×100 mL). The organic layer was separated, dried over sodium sulfate, filtered, and concentrated in vacuo to give 2-methoxy-5-nitro-3-vinylpyridine (4.90 g, 27.2 mmol, >99% yield) as a yellowish-tan solid.
The synthetic route of 15862-50-7 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lanman, Brian A.; Reed, Anthony B.; Cee, Victor J.; Hong, Fang-Tsao; Pettus, Liping H.; Wurz, Ryan P.; Andrews, Kristin L.; Jiang, Jian; McCarter, John D.; Mullady, Erin L.; San Miguel, Tisha; Subramanian, Raju; Wang, Ling; Whittington, Douglas A.; Wu, Tian; Zalameda, Leeanne; Zhang, Nancy; Tasker, Andrew S.; Hughes, Paul E.; Norman, Mark H.; Bioorganic and Medicinal Chemistry Letters; vol. 24; 24; (2014); p. 5630 – 5634;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem