The origin of a common compound about 1H-Pyrrolo[2,3-c]pyridine

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Related Products of 271-29-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.271-29-4, name is 1H-Pyrrolo[2,3-c]pyridine, molecular formula is C7H6N2, molecular weight is 118.14, as common compound, the synthetic route is as follows.

1.1 7.0 g (106 mmol) of potassium hydroxide pellets are added to a solution of 5.00 g (42.3 mmol) of 1H-pyrrolo[2,3-c]pyridine in 80 ml of DMF, and a solution of 10.9 g (42.7 mmol) of iodine in 80 ml of DMF is added dropwise thereto at room temperature and with stirring and stirred for 45 minutes. A solution of 5 ml of 32% ammonia and 1 g of sodium disulfite in 1 l of water is added to the reaction mixture. The resultant precipitate is filtered off with suction, washed with water and dried in vacuo, giving 3-iodo-1H-pyrrolo-[2,3-c]pyridine as orange-yellow solid; ESI 245.

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Reference:
Patent; Merck Patent Gesellschaft Mit Beschrankter Haftung; US2010/292262; (2010); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem