Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 108118-69-0, name is 2,6-Difluoropyridin-3-amine. This compound has unique chemical properties. The synthetic route is as follows. Quality Control of 2,6-Difluoropyridin-3-amine
The mixture of methyl (3R,4S)- 1 -methyl-2-oxo-4- [4-(trifluoromethyl)phenyll -3- pyrrolidinecarboxylate (i.e. the product obtained in Step D above) (5 g, 16.6 mmol), 2,6- difluoropyridin-3-amine (2.37 g, 18.2 mmol) and xylene (45 mL) was heated to the refluxtemperature (142 C) for 10 h, while the methanol generated was distilled out to maintain the pot temperature at 142 C. The progress of reaction was monitored by HPLC until the conversion was greater than 97%. The mixture was concentrated under reduced pressure and purified by silica gel colunm chromatography, eluting with 35% ethyl acetate in hexanes to provide 5.88 g of an off-white solid, which was recrystallized from a mixture of n-chlorobutane (50 mL) and hexanes 75 mL to afford the title product (2.3 g, 99.8% e.e.) as white solid.1H NMR oe 3.02 (s, 3H), 3.48 (dd, 1H), 3.64 (d, 1H), 3.81 (dd, 1H), 4.12 (q, 1H), 6.78 (dd,1H), 7.49 (d, 2H), 7.65 (d, 2H), 8.72 (m, 1H), 10.07 (s, 1H).
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Reference:
Patent; FMC CORPORATION; CHEN, Yuzhong; (56 pag.)WO2018/175226; (2018); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem