Related Products of 1167056-96-3, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1167056-96-3, name is 3-Bromo-5-chloro-1H-pyrrolo[2,3-c]pyridine. This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 3-bromo-5-chloro- 1H- pyrrolo[2,3-c]pyridine (AJ-2) (2.9 g, 12.6 mmol) in anhydrous DMF (100 mL) was added 2- chloro-6-(trifluoromethyl)benzoyl chloride (4.6 g, 18.9 mmol) and NaH (60%) (1 g, 25.2 mmol). The solution was stirred at room temperature for 2 hours. The solution was quenched with H2O(400 mL). The suspension was extracted with EtOAc (150 mL x 3). The combined organic layer was washed with H2O(100 mL x 2) and brine (100 mL x 2) and dried over anhydrous Na2SO4. The solution was evaporated and dried over vacuo and 5.7 g product was obtained. LCMS (ESI) calc?d for C15H6BrCl2F3N2O [M+H]+: 437, found: 437.
According to the analysis of related databases, 1167056-96-3, the application of this compound in the production field has become more and more popular.
Reference:
Patent; MERCK SHARP & DOHME CORP.; BARR, Kenneth, Jay; BEINSTOCK, Corey; MACLEAN, John; ZHANG, Hongjun; BERESIS, Richard, Thomas; ZHANG, Dongshan; WO2014/28589; (2014); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem