Related Products of 108118-69-0, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 108118-69-0 as follows.
To a suspension of l-methyl-lH-pyrrolo[2,3-b]pyridine-5-carboxylic acid (3.54 g, 20.1 mmol) in CH2Cl2 (400 mL) was added l-chloro-N,N-2-trimethylpropenylamine (5.26 mL, 40.2 mmol). Following formation of the resulting acid chloride, the reaction mixture was concentrated affording a residue that was dissolved in pyridine (100 mL) before 2,6- difluoro-pyridin-3-ylamine (2.61 mg, 20.1 mmol) was added in one portion. After an additional 30 minutes the reaction mixture was concentrated to dryness affording a residue, to which was added water causing precipitation o f analytically pure 1 -methyl- 1 H-pyrrolo [2,3 -»]pyridine- 5 – carboxylic acid (2J6-difluoro-pyridin-3-yl)-amide (4.2 g, 72.5% yield). ES MS (M+H+) = 289
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,108118-69-0, its application will become more common.
Reference:
Patent; MERCK & CO., INC.; WO2009/155017; (2009); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem