Related Products of 473927-69-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.473927-69-4, name is 1-(4-Iodophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one, molecular formula is C15H17IN2O2, molecular weight is 384.21, as common compound, the synthetic route is as follows.
Tetramethylethylenediamine (TMEDA, 27.2 mL) was dissolved in THF300 mL) in an inert atmosphere, then cooled to -78C before the drop-wise addition ofn-BuLi (67.6 mL, 2.5 M). 2-bromo-1,3-thiazole (15.2 mL) was added drop-wise and agitation was continued 30 minutes at -78C. Compound 1E (25 g, 139.50 mmol, 1.00 equiv) dissolved in THF (100 mL) was added drop-wise. Agitation was continued for 30 minutes at -78C then 2 hours at -10C. The reaction was neutralised with 500 mLof KHSO4 (sat.), then extracted 3 times with 1 litre of EtOAc. The organic phases were combined, washed twice with 400 mL water and twice with 700 mL of NaC1 (sat.), then dried over sodium sulfate, filtered and concentrated. The residue was purified on a silica column with a mixture of EtOAc and PE (1:100 to 1:10) to yield 25 g (88 %) of compound iF in the form of a yellow oil.
The chemical industry reduces the impact on the environment during synthesis 473927-69-4, I believe this compound will play a more active role in future production and life.
Reference:
Patent; PIERRE FABRE MEDICAMENT; PEREZ, Michel; RILATT, Ian; LAMOTHE, Marie; WO2014/174060; (2014); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem