As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 17570-98-8, name is 2-(Bromoacetyl)pyridine hydrobromide, molecular formula is C7H7Br2NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: pyridine-derivatives
Example 8; (S)-(4-Fluoro-phenyl)(3-(4-(pyridin-2-yl)-oxazol-2-yl)-piperidin-l-yl)-methanone; A solution of (S)-I -(4-fluoro-benzoyl)-piperidine-3-carboxylic acid amide (0.2 g, 0.8 mmol), prepared as described in Example l(C), and 2-(bromoacetyl)-pyridine hydrobromide (90 mg, 0.32 mmol) in dry N-methyl-2-pyrrolidinone (2.5 mL) was heated at 1000C for 5 h. The reaction mixture was cooled to room temperature, ethyl acetate was added and the organic layer was washed sequentially with water (twice) and with brine (twice). The organics were dried over sodium sulphate and evaporated under reduced pressure to afford a crude oil that was purified by flash chromatography: after 3 successive column chromatography purifications (silica gel, eluent: DCM/MeOH/NH4OH 98:2:0.2), 18 mg of (S)-(4-Fluoro-phenyl)(3-(4- (pyridin-2-yl)-oxazol-2-yl)-piperidin-l-yl)-methanone were obtained as a brown oil. Yield: 16%; LCMS (RT): 1.99 min (Method H); MS (ES+) gave m/z: 352.2 (MH+). 1H-NMR (DMSO-d6 353K), delta (ppm): 8.57 (ddd, IH) 8.43 (s, IH) 7.77-7.88 (m, 2H) 7.43-7.50 (m, 2H) 7.28-7.33 (m, IH) 7.19-7.27 (m, 2H) 4.21 (dd, IH) 3.78 (dd, IH) 3.46 (dd, IH) 3.13-3.35 (m, 2H) 2.15-2.28 (m, IH) 1.78-2.01 (m, 2H) 1.52-1.70 (m, IH).
With the rapid development of chemical substances, we look forward to future research findings about 17570-98-8.
Reference:
Patent; ADDEX PHARMA S.A.; WO2008/56259; (2008); A2;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem