Synthetic Route of 64690-19-3, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 64690-19-3 as follows.
B. A mixture of 4-octylaminopyridine (25 g., 0.121 mole) and octyl chloride (20.5 ml., 0.121 mole) was heated at 180 C. for 1 hr. More octyl chloride (0.5 ml.) was added and the mixture was again heated at 180 C. for 1 hr., then dissolved in dichloromethane. The dichloromethane solution was treated with charcoal, filtered, and stripped of solvent under vacuum. The solid residue was slurried in ether (1.5 kg.), collected by filtration, washed with ether (500 g.), isolated in a dry bag, and dried (50-80 C., 0.1 mm.). The procedure was repeated using the same amounts of starting materials and the product were combined, affording N-(1-octyl-4(1H)-pyridinylidene)octanamine monohydrochloride (80.5 g., 93% yield, m.r. 120-125 C.), which is the monohydrochloride salt of the compound of Formula I wherein R and R’ are both octyl.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,64690-19-3, its application will become more common.
Reference:
Patent; Sterling Drug Inc.; US4839372; (1989); A;,
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