Reference of 17322-91-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 17322-91-7, name is 1H-Pyrrolo[3,2-b]pyridin-5(4H)-one. A new synthetic method of this compound is introduced below.
Dissolve 5-hydroxy-1H-pyrrole[3,2]pyridine (10 mmol) in 40 ml of dichloromethane and add 10 ml to it.Triethylamine, controlled temperature below 10 C, adding 2-chloroacetyl chloride (12 mmol) in dichloromethane to the system, adding dropwiseAfter completion, return to room temperature, stir at room temperature for 10 hours, then wash the reaction system with 50 ml of 5% aqueous sodium carbonate solution, organic phase.After drying with anhydrous Na 2 SO 4 and evaporating the solvent, the obtained solid was separated by flash column chromatography.1.9 g pale yellow 2-chloro-1-(5-Hydroxy-1H-pyrrole[3,2]pyridin-1-yl)-ethanone solid, yield 90%.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,17322-91-7, its application will become more common.
Reference:
Patent; Sang Qi; (10 pag.)CN108383838; (2018); A;,
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