Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 929617-30-1, name is 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine. A new synthetic method of this compound is introduced below., Product Details of 929617-30-1
Into a 30 mL sealed tube was placed 5-bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine (900 mg, 4.24 mmol), Pd(dppf)CI2 (315 mg, 0.43 mmol), KOAc (1.25 g, 12.7 mmol) and N,N- dimethylformamide (10 mL). This was followed by the addition of methanol (10 mL) and CO gas. The solution was stirred for 1 h overnight at 80C in an oil bath. The mixture was concentrated under vacuum. The residue was purified over a silica gel column with dichloromethane/methanol (20:1). This resulted in 0.60 g (74%) of methyl 3-methyl-1H- pyrazolo[3,4-c]pyridine-5-carboxylate as a brown solid.
If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 929617-30-1, 5-Bromo-3-methyl-1H-pyrazolo[3,4-c]pyridine.
Reference:
Patent; MERCK PATENT GMBH; CANCER RESEARCH TECHNOLOGY LTD.; SCHIEMANN, Kai; MALLINGER, Aurelie; (147 pag.)WO2016/26549; (2016); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem