Related Products of 13535-01-8, Adding some certain compound to certain chemical reactions, such as: 13535-01-8, name is 5-Bromopyridin-3-amine,molecular formula is C5H5BrN2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 13535-01-8.
To a solution of 5-bromopyridin-3-amine (XIX) (535 mg, 3.09 mmol) in MeOH (62 mL) was added acetone (296 tL, 4.02 mL). The pH was adjusted to 4 using HOAc and stirred for 30 mi NaCNBH3 (272 mg, 4.33 mmol) was added and stirred at room temperature overnight. The MeOH was removed under vacuum and the residue was partitioned between EtOAc and saturated aqueous NaHCO3. The organic layer was dried over Mg504 and evaporated under vacuum. The cmde product was purified on a silica gel column (100% hexanes -* 90:10 hexanes:EtOAc) to produce 5-bromo-N-isopropylpyridin-3-amine (XXXVII) as an oil which slowly solidified into an off-white solid (309 mg, 1.44 mmol, 47% yield). ?H NMR (DMSO-d6, 500 MHz) ppm 1.12 (d, J6.3Hz, 6H), 3.55-3.59 (m, 1H), 6.03 (d, J7.9Hz, 1H), 7.05-7.06 (m, 1H), 7.75 (d, J2Hz, 1H), 7.90 (d, J2Hz, 1H); ESIMS found C8H,,BrN2 mlz 215.1 (M+H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 13535-01-8, 5-Bromopyridin-3-amine, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; SAMUMED, LLC.; KC, Sunil Kumar; WALLACE, David Mark; CAO, Jianguo; CHIRUTA, Chandramouli; HOOD, John; (240 pag.)WO2017/23975; (2017); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem