Related Products of 150114-71-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 150114-71-9 as follows.
10. Preparation of 4-Amino-3,6-dichloro-5-fluoropyridine-2-carboxylic Acid (Compound 19) To a solution of 4-amino-3,6-dichloropyridine-2-carboxylate (1.5 g, 6.8 mmol) in 20 mL of dry acetonitrile was added 1-(chloromethyl)-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis (tetrafluoroborate) (Selectfluor from Aldrich Chemical Company, Inc.; 2.9 g, 2.59 mmol [F+]/g). The resulting mixture was heated at reflux for 3 hr, then allowed to cool to room temperature. This material was taken up in Et2O and washed with H2O. The organic layer was dried over MgSO4, filtered and concentrated to yield a brown oil. The crude product was purified via reverse phase HPLC (50% acetonitrile/water) to give 0.37 g of white solid which was stirred in 1N NaOH for 1 hr then made acidic with conc. HCl. The precipitated white solid was collected with suction, washed with H2O and dried under vacuum to give 170 mg of 4-amino-3,6-dichloro-5-fluoropyridine-2-carboxylic acid (11% yield); mp 214 C. dec.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,150114-71-9, its application will become more common.
Reference:
Patent; Dow AgroSciences LLC; US6297197; (2001); B1;,
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