Adding a certain compound to certain chemical reactions, such as: 893423-62-6, tert-Butyl (2-chloro-3-formylpyridin-4-yl)carbamate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 893423-62-6, blongs to pyridine-derivatives compound. Application In Synthesis of tert-Butyl (2-chloro-3-formylpyridin-4-yl)carbamate
4-Amino-2-chloronicotinaldehyde (1-5c) Trifluoroacetic acid (17.4 mL, 234 mmol) was added carefully to a stirred mixture of Boc aldehyde 1-4 (20 g, 78.1 mmol) and dichloromethane (60 mL) keeping the temperature below 25 C. The solution was warmed to 35 C., aged overnight (vigorous off-gassing) and then cooled to room temperature. 25 mL of MTBE was added and the resulting white slurry was aged for one hour, filtered, and the filter cake rinsed with MTBE (10 mL*2). Solid 1-5c TFA salt was dried under vacuum.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,893423-62-6, its application will become more common.
Reference:
Patent; Kelly, Michael J.; Layton, Mark E.; Sanderson, Philip E.; US2008/161317; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem