Adding a certain compound to certain chemical reactions, such as: 52687-85-1, Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride, blongs to pyridine-derivatives compound. Recommanded Product: Imidazo[1,2-a]pyridin-2(3H)-one hydrochloride
EXAMPLE 1 STR11 A mixture of 341 g (2 mols) of imidazo[1,2-a]pyridin-2(3H)-one hydrochloride and 700 ml of water is treated with portions of a solution of 80 g (2 mols) of sodium hydroxide in 200 ml of water, with stirring. A solution of 250.7 g (2.16 mols) of maleic acid in 600 ml of water is then added dropwise in such a way that the internal temperature of the reaction mixture remains between 40 C. and 45 C. After 30 hours at room temperature (20-25 C.), the mixture is cooled to 5 C., the precipitate formed is filtered off, the filtrate is concentrated to about half its volume in vacuo, and the product which has precipitated is filtered off with suction. The combined residues are washed with a small amount of cold methanol and dried at 50 C. in vacuo. This gives 400 g of 3-(1,2-dicarboxyethyl)-imidazo[1,2-a]pyridin-2(3H)-one with a melting point of 193 (decomposition).
The synthetic route of 52687-85-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Ciba-Geigy Corporation; US4480106; (1984); A;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem