Adding a certain compound to certain chemical reactions, such as: 17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2-(Bromoacetyl)pyridine hydrobromide, blongs to pyridine-derivatives compound. Quality Control of 2-(Bromoacetyl)pyridine hydrobromide
Preparation 20C; 2-(2-(4-iodophenvn-1 -(6-methylpyridin-3-vO-1 H-imidazol-4-yl)pvridi?e; A solution of 4-iodo-N’-(6-methylpyridin-3-yl)benzamidine (23.0 g, 68.2 mmol) in anhydrous THF (150 mL) was treated at 0 0C with LiHMDS (150 mL of 1M in THF, 150 mmol). The resulting solution was treated after 15 min with 2-bromo-1-(pyridin-2-yl)ethanone hydrobromidtheta (19.1 g, 68.2 mmol) and the resulting mixture stirred at RT for 18h. Water (300 mL) and EtOAc (200 mL were added. The aqueous layer was separated and extracted with EtOAc (2 x 200 mL). The combined organic layers were dried and concentrated and the residue heated in acetic acid (200 mL) at 90 0C for 30 min. The mixture was concentrated and the residue partitioned between DCM (300 mL) and excess 2N NaOH. The aqueous layer was separated and extracted with DCM (3 x 200 mL). The combined organic layers were washed with aqueous 10% citric acid (3 x 100 mL), water, brine, dried, and concentrated. The residue was purified by SGC (0-1% MeOH in DCM1 0.5% NH4OH) giving 7.6 g of product which was triturated with ether. Yield 6.5 g, 20%. 1H NMR (CDCI3) delta 8.56 (ddd, 1H, J = 0.8, 1.7, 4.8 Hz), 8.46 (d, 1H1 J = 2.5 Hz), 8.10 (d, 1H, J = 7.9 Hz)1 7.89 (br, 1H), 7.77 (dt, 1H, J =
At the same time, in my other blogs, there are other synthetic methods of this type of compound,17570-98-8, 2-(Bromoacetyl)pyridine hydrobromide, and friends who are interested can also refer to it.
Reference:
Patent; PFIZER PRODUCTS INC.; WO2008/4117; (2008); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem