Application of 917364-11-5 , The common heterocyclic compound, 917364-11-5, name is 5,6,7,8-Tetrahydroimidazo[1,2-a]pyridine-2-carboxylic acid, molecular formula is C8H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.
Step (c) N-((l s,4s)-4-(5-fluor o-2-(3-iodophenoxy)nicotinamido)cyclohexyl)-5,6,7,8- tetrahydroimidazo [ 1 ,2-a] pyridine-2-carboxamideTo a solution of 5,6,7, 8-tetrahydroimidazo[l,2-a]pyridine-2-carboxylic acid (0.183 g, 1.10 mmol) in dry DMF (10 niL) was added DIPEA (0.575 mL, 3.29 mmol) followed by HATU (0.418 g, 1.10 mmol). The mixture was allowed to stir for 10 min at RT. To this mixture was added the N-((ls,4s)-4-aminocyclohexyl)-5-fluoro-2-(3-iodophenoxy Nicotinamide (0.5 g, 1.10 mmol) and the mixture stirred overnight, poured onto water and the crude product collected by filtration, dried in vacuo to give the sub-title compound. Yield: 0.354 g 1H NMR (300 MHz, CDCl3) delta 8.36 (dd, J= 8.0, 3.0 Hz, IH), 8.06 (d, J= 3.1 Hz, IH), 7.86 (d, J= 7.3 Hz, IH), 7.64 (dt, J= 7.2, 1.3 Hz, IH), 7.55 (t, J= 1.8 Hz, IH), 7.40 (s, IH), 7.23 – 7.12 (m, 2H), 6.94 (d, J= 7.3 Hz, IH), 4.20 (s, IH), 4.08 (d, J= 3.5 Hz, IH), 3.98 (t, J= 8.6 Hz, 3H), 2.85 (q, J= 6.2 Hz, 2H), 2.05 – 1.73 (m, HH). [M+H]+ =604 (MultiMode+)
The synthetic route of 917364-11-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem