Application of 153813-70-8, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 153813-70-8, name is 3-Nitroisonicotinaldehyde. This compound has unique chemical properties. The synthetic route is as follows.
Intermediate 11: Methyl 2- [(tert-butoxvcarbonyl) amino] -3-(3nitropyridin-4-yl) acrylate; Methyl [(tert-butoxycarbonyl)amino](dimethoxyphosphoryl)acetate (1.73 g, 5.82 mmol) was dissolved in dry THF (20 ml) and cooled to -78 C under nitrogen. Tetramethylguanidine (638 mg, 5.55 mmol) was added and the solution stirred at -78 C for a further 10 mins. A solution of 3-nitroisonicotinaldehyde (Intermediate 12,804 mg, 5.29 mmol) in dry THF (5ml) was added dropwise. The resulting deep red solution was stirred for 2hrs. at -78C, then poured into a mixture of ethyl acetate (100 ml) and water (50 ml). The organic layer was separated, washed with water (2 x 50 ml) and brine (25 ml), dried (MgS04) and evaporated under reduced pressure to give a yellow oil, which was purified by column chromatography (EtOAc: isohexane 1:1) to give methyl-2-[(tert-butoxycarbonyl)amino]-3-(3-nitropyridin-4- yl) acrylate as a 10: 1 mixture of Z/E isomers (1.57 g, 92%). ¹H NMR: 1.3 (s, 9H); 1.4 (s, 0.9H) ; 3.55 (s, 0.3H) ; 3.8 (s, 3H) ; 6.6 (s, O.IH); 7.2 (s, 1H); 7.25 (d, 0.1H); 7.5 (d, 1H); 8.75 (d, O.1H); 8.8 (s, 1.1H); 8.85 (d, 1H); 9.2 (s, O.1H); 9.25 (s, 1H); MS: 322.
While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 153813-70-8, 3-Nitroisonicotinaldehyde.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2005/123685; (2005); A1;,
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