In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 42959-38-6, name is 2-Chloro-5-nitronicotinic acid, the common compound, a new synthetic route is introduced below. Computed Properties of C6H3ClN2O4
To 2-chloro-5-nitronicotinic acid (1.0 mmol) in methanol was added a solution of sodium methoxide in methanol (2.4 mmol, freshly prepared from sodium metal in methanol). The solution was refluxed for 2 h and the mixture was allowed to cool and concentrated in vacuo. To the resulting residue was added 10% citric acid solution (20 ml) and the solution extracted with ethyl acetate (20 ml). The organic layer was dried (MgS04) and concentrated in vacuo. The residue was crystallised from water to give a yellow-white solid (73%). (0184) ESIMS: M-l 197. (0185) 1H NMR (300 MHz, DMSO) d 9.30 (1H, d, H-4), 8.83 (1H, d, H-6), 4.05 (3H, s, OCH3).
The synthetic route of 42959-38-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BIONOMICS LIMITED; O’CONNOR, Sue; RATHJEN, Deborah; (55 pag.)WO2019/109150; (2019); A1;,
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