Synthetic Route of 628-13-7, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 628-13-7, name is Pyridinehydrochloride. A new synthetic method of this compound is introduced below.
4-(5-Hydroxy-benzofuran-2-yl)-benzoic acid 128 A mixture of 4-(5-Methoxy-benzofuran-2-yl)-benzoic acid methyl ester (0.5 g, 1.8 mmol) and Pyridine HCl (5 g) was heated to 200 C. After 2 hr, the reaction was cooled and poured into water and exracted with EtOAc. The EtOAc layer was dried over MgSO4, concentrated and the product was purified by column chrmatography on silica gel (75% EtOAc/hex) to give a solid (0.21 g, 47%): 1H NMR (DMSO-d6) delta 13.07 (br s, 1H), 9.29 (br s, 1H), 8.02 (d, 2H, J=8.1 Hz), 7.97 (d, 2H, J=8.7 Hz), 7.46 (m, 2H), 6.97 (d, 1H, J=2.9 Hz), 6.79 (dd, 1H, J=9.3 Hz, 2.9 Hz); MS 253 (M-H)-
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,628-13-7, its application will become more common.
Reference:
Patent; Wyeth; US2003/171428; (2003); A1;,
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem